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CBD, yoga and anxiety: what two clinical trials found

A yoga trial measured improvement over 12 weeks; a small CBD experiment measured anxiety during public speaking. Their results describe different interventions.

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Two interventions with different evidence

Yoga and cannabidiol have both been investigated for anxiety, but in different settings. A 2020 trial examined a structured Kundalini-yoga programme in adults with generalised anxiety disorder. A 2011 experiment examined cannabidiol during simulated public speaking in people with social anxiety disorder. The first studied repeated behavioural practice; the second studied an acute pharmacological intervention. Those concrete differences explain more than the broad promise of a relaxing combination.

[1] Simon et al. ·2020 yoga anxiety trial[2] Bergamaschi et al. ·2011 CBD trial[3] EMA ·cannabidiol medicine safety

The yoga trial included 226 adults

The 2020 randomised trial compared twelve weeks of Kundalini yoga, cognitive behavioural therapy and stress education. Response rates were 54.2% for yoga,70.8% for CBT and 33.0% for stress education. Both active treatments outperformed the education control, but the study did not establish yoga as noninferior to CBT. Its result supports a benefit for the tested programme while preserving the stronger position of CBT in that comparison.

[1] Simon et al. ·2020 yoga anxiety trial

The CBD experiment tested a stressful task

The 2011 study randomly assigned 24 previously untreated social-anxiety patients to cannabidiol or placebo;12 healthy controls also completed the speaking test. The CBD group showed reduced anxiety, cognitive impairment and discomfort during the speech compared with placebo. The experiment concerned one laboratory session and a defined patient group. Its endpoint was a response to public speaking, rather than the effect of a daily yoga routine.

[2] Bergamaschi et al. ·2011 CBD trial

What combining them would add

Neither trial tested CBD added to yoga, so their results cannot establish an extra benefit from the combination. Combining interventions would introduce a new comparison: yoga alone versus the same programme with CBD, with both benefits and adverse effects measured. Cannabidiol also has a pharmacological safety profile, including interactions and possible liver effects in medicinal use. The demonstrated findings remain specific: structured yoga improved anxiety outcomes in one trial, and CBD reduced task-related anxiety in a small separate experiment.

[1] Simon et al. ·2020 yoga anxiety trial[2] Bergamaschi et al. ·2011 CBD trial[3] EMA ·cannabidiol medicine safety

Sources & further reading

General information, not individual legal or medical advice.